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Arizona Cardinals vs San Francisco 49ers: Kyler Murray Leads the Charge in NFC West Showdown

First Quarter


As the Arizona Cardinals prepare to face off against the San Francisco 49ers, all eyes are on quarterback Kyler Murray. Known for his dynamic playmaking abilities, Murray is expected to be a key factor in the opening quarter. The Cardinals will aim to capitalize on their home advantage at State Farm Stadium, with betting lines showing a slight edge towards the Niners. MGM lists the Cardinals at +100 odds, while FanDuel offers a more favorable +134 for Arizona. The 49ers are favored across most books, with odds ranging from -120 to -158.


Arizona Cardinals quarterback Clayton Tune (15) runs with the ball during an NFL football game against the Cleveland Browns, Sunday, Nov. 5, 2023, in Cleveland. (AP Photo/Kirk Irwin)

Second Quarter


Heading into the second quarter, both teams will likely adjust their strategies based on early performances. The spread has shifted slightly in favor of San Francisco, now sitting at -2.5 according to DraftKings and FanDuel. This change suggests confidence in the Niners' ability to maintain pressure throughout the game. However, with players like James Conner and Greg Dortch supporting Murray's efforts, Arizona could surprise bettors who have leaned towards San Francisco.


Third Quarter


The third quarter is often pivotal in determining momentum shifts. As it stands, total points predictions hover around 47.5 across most platforms like MGM and PointsBet. Interestingly, Bet365.US.NJ has adjusted its total to 43.5, indicating expectations of a tighter defensive battle as both teams vie for control in this NFC West clash.


Fourth Quarter


In the final quarter, expect both teams to push hard for victory. With Arizona's defense led by standouts like Budda Baker and Zaven Collins, they could potentially stifle San Francisco's offensive threats late in the game. The consensus moneyline currently favors San Francisco at -140 but remains competitive with Arizona's +120 odds offering value for those backing an upset.


The showdown between these division rivals promises excitement and unpredictability as fans wonder who will win Arizona Cardinals vs San Francisco 49ers? Scheduled for November 16th at State Farm Stadium in Glendale, AZ, this game will be broadcast live on FOX at 4:05 PM EST. Don't miss out on this thrilling encounter; tune in and share your thoughts on who you think will emerge victorious!

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