Jacksonville Jaguars vs Arizona Cardinals: Travis Etienne's Impact in Glendale Showdown

First Quarter

As the Jacksonville Jaguars prepare to face off against the Arizona Cardinals, the betting lines are drawing significant attention. The opening odds have shifted considerably, with the Jags now favored at -120 on DraftKings, a notable change from their initial +130 odds. This shift suggests growing confidence in Jacksonville's ability to perform well on the road. Meanwhile, the Cardinals' odds have moved from -155 to +100, indicating a potential underdog status despite playing at home.

Second Quarter

The spread has also seen movement, with Jacksonville now sitting at -1.5 across most sportsbooks. This adjustment reflects bettors' belief in the Jags' potential to cover against a Cardinals team that has shown vulnerabilities this season. FanDuel lists Jacksonville at -105 for covering the spread, while Arizona is at -115 for their +1.5 line.

Third Quarter

Total points projections have been adjusted downward from an opening 47.5 to 45.5 across various platforms like BetRivers and Bet365.US.NJ. This change suggests expectations of a tighter defensive battle or less scoring prowess from both sides than initially anticipated. The over/under odds remain balanced around -110, showing no clear consensus on whether this will be a high or low-scoring affair.

Fourth Quarter

In terms of head-to-head matchups, both teams have had mixed results in recent encounters. The Jaguars' running back Travis Etienne is expected to play a pivotal role in breaking through Arizona's defense, which could be crucial given his current form and impact on games this season.

As fans gear up for this exciting clash between the Jags and Redbirds at State Farm Stadium in Glendale, they can catch all the action live on CBS at 4:05 PM ET on November 23rd, 2025.

For those looking into Jacksonville Jaguars vs Arizona Cardinals betting tips and insights into the Jacksonville Jaguars vs Arizona Cardinals betting line, it's essential to consider these shifts and trends as game day approaches.

Don't miss out on sharing your thoughts and predictions for this thrilling matchup!