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NFL - Odds, Watch, Predictions

Indianapolis Colts vs San Francisco 49ers: Jonathan Taylor's Impact in the Upcoming Clash

December 16, 2025

As the Indianapolis Colts prepare to face off against the San Francisco 49ers, fans and bettors alike are keenly watching the opening quarter. The Colts, led by standout running back Jonathan Taylor, will look to establish their ground game early. Betting lines from MGM show the Colts as underdogs with odds of +225, while the Niners are favored at -275. This disparity highlights the challenge ahead for Indianapolis, but Taylor's explosive play could shift momentum in their favor.

NFL - Odds, Watch, Predictions

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