Isaac Guerendo

Isaac Guerendo is an emerging talent in the NFL, playing for the San Francisco 49ers. Born on June 28, 2000, in Clayton, Indiana, Guerendo attended Avon High School. He later played college football at Louisville, where he developed his skills as a running back. In the 2024 NFL Draft, Guerendo was selected by the 49ers in the fourth round, with the 129th overall pick. Standing at 72 inches tall and weighing 221 pounds, he wears jersey number 31 and is known for his agility and strength on the field. During the 2025 preseason, Guerendo showcased his potential in a game where he had eight rushing attempts, covering 13 yards with a longest run of five yards. He also managed a reception for one yard. Despite facing challenges, his dedication and work ethic have been evident. Throughout the 2025 regular season, Guerendo played 14 games. His special teams contributions included five kick returns, accumulating 100 yards, with an average of 20 yards per return. His longest kick return was 25 yards. Additionally, he recorded two special teams tackles and forced a fumble, demonstrating his defensive capabilities. As Isaac Guerendo continues to evolve in his NFL career, his journey from a promising college player to a professional athlete in the NFL remains one to watch. His performance reflects a promising start in the league, with potential for further development in future seasons.